Mooroopna is a town located 181 kilometres (112 mi) north of Melbourne, Victoria, Australia. It is on the banks of the Goulburn River opposite the larger town of Shepparton. The Midland Highway crosses the river between the two towns. On the 30th June 2022, Mooroopna had a population of 8,921.

V/Line services on the Shepparton line stop at the local railway station, which is also served by Pacific National operated container freight services for Patrick PortLink.