Denistone West is a suburb in Northern Sydney, in the state of New South Wales, Australia. Denistone West is located 16 kilometres north-west of the Sydney central business district in the local government area of the City of Ryde. Denistone and Denistone East are separate suburbs; Denistone West was gazetted as a suburb in its own right on 5 February 1999.

Denistone railway station is situated in the suburb of Denistone. Denistone West is serviced by one Busways routes, 544, which connect to Eastwood, Auburn and Macquarie Park.