Booleroo Centre is a town in the southern Flinders Ranges region of South Australia. The town is located in the Mount Remarkable District Council local government area, 282 kilometres (175 mi) north of the state capital, Adelaide. At the 2006 census, Booleroo Centre had a population of 516.

Booleroo Centre was serviced by the Wilmington railway line from 1910 until 1969. In 1884 the portion of railway between Gladstone and Laura was opened, but did not reach to Booleroo Centre. Coaches took travellers to the railhead. Agitation went on for many years until, in 1910, the first railway to Booleroo Centre was opened by the South Australian Railways. The new 3 ft 6 in (1,067 mm) (narrow) gauge line ran 24.25 miles (39 kilometres) between Laura and Booleroo Centre. The line was extended to Wilmington in 1915. The railway greatly facilitated the shipment of locally produced bagged wheat through Gladstone to export ports such as Port Pirie. In 1910 there were 100,000 bags of wheat stacked at Booleroo. It also provided valuable passenger services for many decades, until improvements in road transport began to replace rail, resulting in ceasing passenger service in 1969 and eventual closure in 1982.