Loxton is a town on the south bank of the River Murray in the Riverland region of South Australia. It is located on the lands of the Erawirung people who occupied the area before the arrival of Europeans.

The first form of regular transport to Loxton was paddle steamers on the Murray River. The Loxton railway line, completed in 1914, connected Alawoona and Tailem Bend to Adelaide. Loxton today is connected by road to the Sturt Highway, which passes nearby at Kingston On Murray and is the northern terminus of the Karoonda Highway and eastern terminus of the Stott Highway. The railway line now terminates at the Tookayerta grain terminal 7 kilometres (4 miles) south of the town and does not carry any passengers. The line was closed in 2015.