Waikerie ( WAY-kə-ree ) is a rural town in the Riverland region of South Australia on the south bank of the Murray River. At the 2016 census, Waikerie had a population of 2,684. The Sturt Highway passes to the south of the town at the top of the cliffs. There is a cable ferry crossing the river to provide vehicle access from the north side of the river. Waikerie is known for citrus growing, along with stone fruit and grapes.

The Sturt Highway passes to the south of the town at the top of the cliffs. Waikerie was once the terminus of the Waikerie railway line from 1914 until 1990.