Wye River is a small town in Victoria, Australia. It is also the name given to the waterway which flows through the town and into the sea. Situated 155 km to the west of Melbourne, on the Otway Coast, part of the scenic Great Ocean Road, the Wye River township is located about 15 km west of the resort town Lorne, Victoria. It became more feasible for Melburnians to holiday there after the section of the Great Ocean Road from Lorne to Apollo Bay was opened in 1932. At the 2016 census, Wye River had a permanent population of 66, although its holiday population is ten times that.

Automobiles are the main form of transport to get to and from the town, via the Great Ocean Road. Within the town, most people walk between destinations. Wye River is serviced by the 101 V/Line coach that travels between Geelong Station and Apollo Bay in both directions.